発表論文リスト

2024

  • Okamoto H, Fujio K, Nakamura S, Harada Y, Hayashi H, Higashi  N, Ninomiya A, Tanaka R, Sugimoto N, Takayama N, Kaneda A, Sawaguchi A, Kato Y & Eto K. Defective flow space limits the scaling up of turbulence bioreactors for platelet generation. Communications Engineering 3, 77 (2024). https://doi.org/10.1038/s44172-024-00219-y
  • Chen SJ, Hashimoto K, Fujio K, Hayashi K, Paul SK, Yuzuriha A, Qiu WY, Nakamura E, Kanashiro MA, Kabata M, Nakamura S, Sugimoto S, Kaneda A, Yamamoto T, Saito H, Takayama N & Eto K.  A let-7 microRNA-RALB axis links the immune properties of iPSC-derived megakaryocytes with platelet producibility. Nature Communications 15, 2588 (2024). https://doi.org/10.1038/s41467-024-46605-0

2023

  • Flahou C, Morishima T, Higashi N, Hayashi Y, Xu H, Wang B, Zhang C, Ninomiya A, Qiu WY, Yuzuriha A, Suzuki D, Nakamura S, Manz M, Kaneko S, Hotta A, Takizawa H, Eto K, & Sugimoto N. Humanized mouse models with endogenously developed human natural killer cells for in vivo immunogenicity testing of HLA class I-edited iPSC-derived cells. Biochemical and biophysical research communications, 662, 76–83 (2023). https://doi.org/10.1016/j.bbrc.2023.04.067

2022

  • Chen SJ, Sugimoto N, Eto K. Ex vivo manufacturing of platelets: beyond the first-in-human clinical trial using autologous iPSC-platelets. Int.J.Hematol., 2022, Dec 27.doi: 10.1007/s12185-022-03512-8.
  • Sugimoto N, Nakamura S, Shimizu S, Shigemasa A, Kanda J, Matsuyama N, Tanaka M, Hayashi T, Fuchizaki A, Nogawa M, Watanabe N, Okamoto S, Handa M, Sawaguchi A, Momose D, Koh KR, Tani Y, Takaori-Kondo A, Eto K. Production and nonclinical evaluation of an autologous iPSC-derived platelet product for the iPLAT1 clinical trial. Blood advances, 2022, Sep 23.doi: 10.1182/bloodadvances.2022008512.
  • Sugimoto N, Kanda J, Nakamura S, Kitano T, Hishizawa M, Kondo T, Shimizu S, Shigemasa A, Hirai H, Arai Y, Minami M, Tada H, Momose D, Koh KR, Nogawa M, Watanabe N, Okamoto S, Handa M, Sawaguchi A, Matsuyama N, Tanaka M, Hayashi T, Fuchizaki A, Tani Y, Takaori-Kondo A, Eto K. iPLAT1: The first-in-human clinical trial of iPSC-derived platelets as a phase 1 autologous transfusion study. Blood, 2022, Sep 16. doi: 10.1182/blood.2022017296.
  • Elagib KE, Brock A, Clementelli CM, Mosoyan G, Delehanty LL, Sahu RK, Pacheco-Benichou A, Fruit C, Besson T, Morris SW, Eto K, Jobaliya C, French DL, Gadue P, Singh S, Shi X, Qin F, Cornelison R, Li H, Inacu-Rubin C, Goldfarb AN. Relieving Dyrk1a repression of MLK1 confers an adult-like phenotype to human infantile megakaryocytes. J Clin Invest. 2022, 132 (19):1-13. doi: 10.1172/JCI154839
  • Itokawa N, Oshima M, Koide S, Takayama N, Kuribayashi W, Nakajima-Takagi Y, Aoyama K, Yamazaki S, Yamaguchi K, Furukawa Y, Eto K, Iwama A. Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells. Nat Commun., 2022, 13(1):1-15. doi: 10.1038/s41467-022-30440-2

2021

  • Sone M*, Nakamura S*, Umeda S, Ginya H, Oshima M, Kanashiro MA, Sudip Paul SK, Hashimoto K, Nakamura E, Harada Y, Tsujimura K, Saraya A, Yamaguchi T, Sugimoto N, Sawaguchi A, Iwama A, Eto K, and Takayama N. Silencing of p53 and CDKN1A establishes sustainable immortalized megakaryocyte progenitor cells from human iPSCs. Stem Cell Reports, 2021, 16, 12:P2861-2870. doi: 10.1016/j.stemcr.2021.11.001
  • Flahou C, Morishima T,Takizawa H, Sugimoto N. Fit-For-All iPSC-Derived Cell Therapies and Their Evaluation in Humanized Mice With NK Cell Immunity. Frontiers in Immunology, 2021, April 2 doi: 10.3389/fimmu.2021.662360
  • Yuzuhira A, Nakamura S, Sugimoto N, Kihara S, Nakagawa M, Yamamoto T, Sekiguchi K, Eto K. Extracellular laminin regulates hematopoietic potential of pluripotent stem cells through Integrin β1-ILK-β-catenin-JUN axis.  Stem Cell Research, 2021, March 16 doi.org/10.1016/j.scr.2021.102287
  • Sakuma S, Kumon H, Nakamura S, Kasai Y, Eto K, Arai F. Three‐dimensional microchannel reflecting cell size distribution for on‐chip production of platelet‐like particles.  Microfluidics and Nanofluidics, 2021, 25:36. doi.org/10.1007/s10404-021-02433-y
  • Nakamura S, Sugimoto N, Eto K. Development of platelet replacement therapy using human induced pluripotent stem cells. Development, Growth & Differentiation, 2021 Jan 28. doi: 10.1111/dgd.12711.
  • Oku M, Ishino R, Uchida S, Imataki O, Sugimoto N, Todo T, Kadowaki N. Oncolytic herpes simplex virus type 1 (HSV-1) in combination with lenalidomide for plasma cell neoplasms. Br J Haematol. 2021 Jan;192(2):343-353. doi: 10.1111/bjh.17173.
  • Kikuchi M, Onodera A, Kokubo K, Ichikawa T, Moromoto Y, Kawakami E, Takayama N, Eto K, Koseki H, Hirahara K, Nakayama T. The Cxxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation. J. Exp. Med. 2021 Apr 5;218(4): e20201690. doi: 10.1084/jem.20201690.
  • Kato H, Maezawa Y, Takayama N, Ouchi Y, Kaneko H, Kinoshita D, Takada-Watanabe A, Oshima M, Koshizaka M, Ogata H, Kubota Y, Mitsukawa N, Eto K, Iwama A, Yokote K. Fibroblasts from different body parts exhibit distinct phenotypes in adult progeria Werner syndrome. Aging (Albany NY), 2021 Feb 24;13(4):4946-4961. doi: 10.18632/aging.202696.
  • Sato M , Shiga Y, Takayama N , Sone M , Kosaka K, Motegi I , Mizuki N, Inage K, Eguchi Y, Narita M, Orita S, Eto K, Ohtori S. The effect of megakaryocytes and platelets derived from human induced pluripotent stem cells on bone formation. Supine Surgery and Related Research, 2021, doi: dx.doi.org/10.22603/ssrr.2020-0226

2020

  • Suzuki D, Flahou C, Yoshikawa N, Stirblyte I, Hayashi Y, Sawaguchi A, Akasaka M, Nakamura S, Higashi N, Xu H, Matsumoto T, Fujio K, Manz MG, Hotta A, Takizawa H, Eto K, Sugimoto N. iPSC-derived platelets depleted of HLA class-I are inert to anti-HLA class-I and NK cell immunity.  Stem Cell Reports, 2020, 14: 49-59.doi.org/10.1016/j.stemcr.2019.11.01

  • Flahou C, Sugimoto N, Eto K. Novel platelet pharming using human induced pluripotent stem cells. Bull Acad Natl Med, 2020, 204(9):961-970. doi: 10.1016/j.banm.2020.09.040.

  • Nakamura S, Sugimoto N, Eto K. Ex vivo generation of platelet products from human iPS cells. Inflamm Regen. 2020, 1;40(1):30. doi: 10.1186/s41232-020-00139-2.

2019

  • Eto K. Platelets using iPS cell technology; large scale manufacturing. J Stem Cells Regen Med. 2019; 15(2): 52.doi: 10.46582/jsrm.1502010

  • Takaishi K, Takeuchi M, Tsukamoto S, Takayama N, Oshima M, Kimura K, Isshiki Y, Kayamori K, Hino Y, Oshima-Hasegawa N, Mitsukawa S, Takeda Y, Mimura N, Ohwada C, Iseki T, Nakamura S, Eto K, Iwama A, Yokote K, Nakaseko C, Sakaida E. Suppressive Effects Of Anagrelide On Cell Cycle Progression And The Maturation Of Megakaryocyte Progenitor Cell Lines In Human Induced Pluripotent Stem Cells. Haematologica, 2019.104.doi:10.3324/haematol.2018.214841
  • Kasirer-Friede A, Tjahjono W., Eto K, Shattil SJ. SHARPIN at the Nexus of Platelet Integrin, Immune and Inflammatory Signaling. Proc Natl Acad Sci USA. Mar12;116(11):4983-4988, 2019.  doi: 10.1073/pnas.1819156116. 
  • Yamamoto K, Kitawaki T, Sugimoto N, Fujita H, Kawase Y, Takaori-Kondo A, Kadowaki N. Anti-inflammatory modulation of human myeloid-derived dendritic cell subsets by lenalidomide. Immunol Lett. 2019 Jul;211:41-48. doi: 10.1016/j.imlet.2019.05.012. 
  • Sugimoto N, Eto K. Reconstitution of the hematopoietic system and clinical applications of iPS cells. Rinsho Ketsueki. 2019;60(9):1046-1055. doi: 10.11406/rinketsu.60.1046. 
  • Sugimoto N, Eto K. αIIbβ3 changes gears in MKs and platelets. Blood. 2019 Apr 18;133(16):1700-1701. doi: 10.1182/blood-2019-01-896092. 

2018

  • Seo H*, Chen SJ*, Hashimoto K, Endo H, Nishi Y, Ohta A,  Yamamoto T,  Hotta A,  Sawaguchi A,  Hayashi H,  Koseki N,  Murphy GJ,  Fukuda K,  Sugimoto N, and  Eto K. A β1-tubulin-based megakaryocyte maturation reporter system identifies novel drugs that promote platelet production. Blood Advance, 2018, 2: 2262-2272.doi:10.1182/bloodadvances.2018019547
  • Kanaji T, Vo MN, Kanaji S, Zarpellon A, Shapiro R, Morodomi Y, Yuzuriha S, Eto K, Belani R, Do MH, Yang XL, Ruggeri ZM, and Schimmel P. Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia. PNAS.2018 Aug 13. doi: 10.1073/pnas.1807000115 
  • Ito Y*, Nakamura S*, Sugimoto N, Shigemori T, Kato Y, Ohno M, Sakuma S, Ito K, Kumon H, Hirose H, Okamoto H, Nogawa M, Iwasaki M, Kihara S, Fujio K, Matsumoto T, Higashi N, Hashimoto K, Sawaguchi A, Harimoto KI, Nakagawa M, Yamamoto T, Handa M, Watanabe N, Nishi E, Arai F, Nishimura S, Eto K. Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production. Cell. 2018 Jul 26;174(3):636-648.e18. doi: 10.1016/j.cell.2018.06.011. 
  • Kanda K, Sakamoto J, Matsumoto Y, Ikuta K, Goto N, Morita Y, Ohno M, Nishi K, Eto K, Kimura Y, Nakanishi Y, Ikegami K, Yoshikawa T, Fukuda A, Kawada K, Sakai Y, Ito A, Yoshida M, Kimura T, Chiba T, Nishi E, and Seno H. Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation. JCI insight. 2018 April 19;19;3(8):e91316. doi: 10.1172/jci.insight.91316.
  • Takei H, Edahiro Y, Mano S, Masubuchi N, Mizukami Y, Imai M, Morishita S, Misawa K, Ochiai T, Tsuneda S, Endo H, Nakamura S, Eto K, Ohsaka A, Araki M, Komatsu N. Skewed megakaryopoiesis in human induced pluripotent stem cell‐derived haematopoietic progenitor cells harbouring calreticulin mutations. British journal of Haematology. 2018 May 9;181, 791–802.doi: 10.1111/bjh.15266.
  • Toki T, Yoshida K, Wang RN, Nakamura S, Maekawa T, Goi K, Katoh MC, Mizuno S, Sugiyama F, Kanezaki R, Uechi T, Nakajima Y, Sato Y, Okuno Y, Sato-Otsubo A, Shiozawa Y, Kataoka K, Shiraishi Y, Sanada M, Chiba K, Tanaka H, Terui K, Sato T, Kamio T, Sakaguchi H, Ohga S, Kuramitsu M, Hamaguchi I, Ohara A, Kanno H, Miyano S, Kojima S, Ishiguro A, Sugita K, Kenmochi N, Takahashi S, Eto K, Ogawa S, Ito E. De novo mutations activating germline TP53 in an inherited bone marrow failure syndrome. Am J Hum Genet, 103(3):440-447, 2018. Doi: 10.1016/j.ajhg.2018.07.020. Epub 2018 Aug 23.
  •  Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M, Ueno M, Ohta K, Arai Y, Harada K, Oshima M, Oshima H, Arai F, Yoshimura A, Nakauchi H, Hirao A. Spred1 safeguards hematopoietic homeostasis against diet-induced systemic stress. Cell Stem Cell.22(5): 713-725, 2018. doi. 10.1016/j.stem.2018.04.002. Epub 2018 Apr 26.
  • Sugimoto N, Eto K. Ex vivo platelet production from induced pluripotent stem cells. Rinsho Ketsueki. 2018;59(10):1905-1913. doi: 10.11406/rinketsu.59.1905. 

2017

  • Sugimoto N, Eto K. Platelet production from induced pluripotent stem cells. J Thromb Haemost. 2017 Sep;15(9):1717-1727. doi: 10.1111/jth.13736. Epub 2017 Jul 28.
  • Watanabe N, Nogawa M, Ishiguro M, Maruyama H, Shiba M, Satake M, Eto K, Handa M.Refined methods to evaluate the in vivo hemostatic function and viability of transfused human platelets in rabbit models. Transfusion. 2017 Aug;57(8):2035-2044. doi: 10.1111/trf.14189. Epub 2017 Jul 5.
  • Aihara A, Koike T, Abe N, Nakamura S, Sawaguchi A, Nakamura T, Sugimoto N, Nakauchi H, Nishino T, Eto K. Novel TPO receptor agonist TA-316 contributes to platelet biogenesis from human iPS cells. Blood Adv. 2017 Feb 28;1(7):468-476. doi: 10.1182/bloodadvances.2016000844. eCollection 2017 Feb 28.

2016

  • Hirata S, Murata T, Suzuki D, Nakamura S, Jono-Ohnishi R, Hirose H, Sawaguchi A, Nishimura S, Sugimoto N, Eto K. Selective Inhibition of ADAM17 Efficiently Mediates Glycoprotein Ibα Retention During Ex Vivo Generation of Human Induced Pluripotent Stem Cell-Derived Platelets. Stem Cells Transl Med. 2017 Mar;6(3):720-730. doi: 10.5966/sctm.2016-0104. Epub 2016 Oct 5.
  • Eto K, Kunishima S. Linkage between the mechanisms of thrombocytopenia and thrombosis. Blood. 2016 Mar 10;127(10):1234-41. doi: 10.1182/blood-2015-07-607903. Epub 2016 Jan 19. Review.

2015

  • Fujii T, Sakata A, Nishimura S, Eto K, Nagata S. TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets. Proc Natl Acad Sci USA. 2015 Oct 13;112(41):12800-5. doi: 10.1073/pnas.1516594112. Epub 2015 Sep 28.
  • Karagiannis P, Eto K. Manipulating megakaryocytes to manufacture platelets ex vivo. J Thromb Haemost. 2015 Jun;13 Suppl 1:S47-53. doi: 10.1111/jth.12946
  • Nishimura S, Nagasaki M, Kunishima S, Sawaguchi A, Sakata A, Sakaguchi H, Ohmori T, Manabe I, Italiano JE Jr, Ryu T, Takayama N, Komuro I, Kadowaki T, Eto K, Nagai R. IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs. J Cell Biol. 2015 May 11;209(3):453-66. doi: 10.1083/jcb.201410052
  • Eto K. Platelet biogenesis wears silkworm cocoons. Blood. 2015 April 2 ; 125 （14)2181-83
  • Toriumi T, Takayama N, Murakami M, Sato M, Yuguchi M, Yamazaki Y, Eto K, Otsu M, Nakauchi H, Shirakawa T, Isokawa K, Honda MJ. Characterization of mesenchymal progenitor cells in the crown and root pulp of primary teeth. Biomed Res. 2015;36(1):31-45. doi: 10.2220/biomedres.36.31.

2014

  • Nishimura S, Nagasaki M, Okudaira S, Aoki J, Ohmori 4, Ohkawa R, Nakamura K, Igarashi K, Yamashita H, Eto K, Uno K, Hayashi N, Kadowaki T, Komuro I, Yatomi Y, Nagai R. ENPP2 contributes to adipose tissue expansion and insulin resistance in Diet-Induced obesity. Diabetes. 2014 Dec; 63(12):4154-64.
  • Ishii T, Eto K.“Fetal stem cell transplantation: Past, present, and future.”World J Stem Cells. 2014 Sept. 26; 6(4): 404-420.
  • Hosoi M, Kumano K, Taoka K, Arai S, Kataoka K, Ueda K, Kamikubo Y, Takayama N, Otsu M, Eto K, Nakauchi H, Kurokawa M.Generation of induced pluripotent stem cells derived from primary and secondary myelofibrosis patient samples.Exp Hematol. 2014 Sep;42(9):816-25.
  • Ochi K, Takayama N, Hirose S, Nakahata T, Nakauchi H, Eto K.Multicolor staining of globin subtypes reveals impaired globin switching during erythropoiesis in human pluripotent stem cells.Stem Cells Transl Med. 2014 Jul;3(7):792-800.
  • Higuchi T, Kawagoe S, Otsu M, Shimada Y, Kobayashi H, Hirayama R, Eto K, Ida H, Ohashi T, Nakauchi H, Eto K.The generation of induced pluripotent stem cells (iPSCs) from patients with infantile and late-onset types of Pompe disease and the effects of treatment with acid-α-glucosidase in Pompe’s iPSCs.Mol Genet Metab. 2014 May;112(1):44-8.
  • Nakamura S, Takayama N, Hirata S, Seo H, Endo H, Ochi K, Fujita KI, Koike T, Harimoto KI, Watanabe A, Okita K, Takahashi N, Sawaguchi A, Yamanaka S, Nakauchi H, Nishimura S, Eto K. Expandable megakaryocyte cell lines enable clinically-aplicable generation of platelets from human induced pluripotent stem cells. Cell Stem Cell. 2014 Feb 12；14(4):535-548. doi: 10.1016/j.stem.2014.01.011.

2013

  • Hirose S, Takayama N, Nakamura S, Nagasawa K, Ochi K, Hirata S, Yamazaki S, Yamaguchi T, Otsu M, Sano S, Takahashi N, Sawaguchi A, Ito M, Kato T, Nakauchi H, Eto K. Immortalization of erythroblasts by c-MYC and BCL-XL enables large-scale erythrocyte production from human pluripotent stem cells. Stem Cell Reports. 2013 Dec 5;1(6):499-508. doi: 10.1016/j.stemcr.2013.10.010. eCollection 2013.
  • Nishimura S, Manabe I, Takaki S, Nagasaki M, Otsu M, Yamashita H, Sugita J, Yoshimura K, Eto K, Komuro I, Kadowaki T, Nagai R. Adipose natural regulatory B cells negatively control adipose tissue inflammation. Cell Metab. 2013 Oct 22. pii: S1550-4131(13)00386-0. doi: 10.1016/j.cmet.2013.09.017. [Epub ahead of print]
  • Hirata S, Takayama N, Jono-Ohnishi R, Endo H, Nakamura S, Dohda T, Nishi M, Hamazaki Y, Ishii EI, Kaneko S, Otsu M, Nakauchi H, Kunishima S, Eto K. Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling. J Clin Invest. 2013 Sep 3;123(9):3802-14. doi: 10.1172/JCI64721. Epub 2013 Aug 1.
  • Nakagawa Y, Nakamura S, Nakajima M, Endo H, Dohda T, Takayama N, Nakauchi H, Arai F, Fukuda T, Eto K. Two differential flows in a bioreactor promoted platelet generation from human pluripotent stem cell-derived megakaryocytes. Exp Hematol. 2013 Aug;41(8):742-8. doi: 10.1016/j.exphem.2013.04.007. Epub 2013 Apr 22
  • Oda A, Eto K. WASPs and WAVEs: from molecular function to physiology in hematopoietic cells. Semin Cell Dev Biol. 2013 Apr;24(4):308-13. doi: 10.1016/j.semcdb.2013.03.002. Epub 2013 Mar 14
  • Nishimura T, Kaneko S, Kawana-Tachikawa A, Tajima Y, Goto H, Zhu D, Nakayama-Hosoya K, Iriguchi S, Uemura Y, Shimizu T, Takayama N, Yamada D, Nishimura K, Ohtaka M, Watanabe N, Takahashi S, Iwamoto A, Koseki H, Nakanishi M, Eto K, Nakauchi H. Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation. Cell Stem Cell. 2013 Jan 3;12(1):114-26. doi: 10.1016/j.stem.2012.11.002.

2012

  • Kumano K, Arai S, Hosoi M, Taoka K, Takayama N, Otsu M, Nagae G, Ueda K, Nakazaki K, Kamikubo Y, Eto K, Aburatani H, Nakauchi H, Kurokawa M. Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples. Blood. 119(26):6234-42.
  • Takayama N, Eto K. Pluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical application. Cell Mol Life Sci. 2012 Oct;69(20):3419-28. doi: 10.1007/s00018-012-0995-4.
  • Takayama N, Eto K. In vitro generation of megakaryocytes and platelets from human embryonic stem cells and induced pluripotent stem cells. Methods Mol Biol. 788:205-17.

2011

  • Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya K, Petrich B, Urano T, Kadono T, Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, Nagai R. In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling. Blood 119, 45-56.
  • Umemoto T, Yamato M, Ishihara J, Shiratsuchi Y, Utsumi M, Morita Y, Tsukui H, Terasawa M, Shibata T, Nishida K, Kobayashi Y, Petrich B, Hiromitsu Nakauchi , Koji Eto and Teruo Okano. Integrin αvβ3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells. Blood 119, 83-94.
  • Kunishima S, Kashiwagi H, Otsu M, Takayama N, Eto K, Onodera M, Miyajima Y, Takamatsu Y, Suzumiya J, Matsubara K, Tomiyama Y, Saito H. Heterozygous ITGA2B R995W mutation inducing constitutive activation of the aIIbβ3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia. Blood 117, 5479-5484.

2010

  • Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H, Eto K. Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells. J Exp Med 207, 2817-30.
  • Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K. Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo. J Clin Invest 120, 179-90.
  • Hayashi Y, Chan T, Warashina M, Fukuda M, Ariizumi T, Okabayashi K, Takayama N, Otsu M, Eto K, Furue MK, Michiue T, Ohnuma K, Nakauchi H, Asashima M. Reduction of N-glycolylneuraminic acid in human induced pluripotent stem cells generated or cultured under feeder- and serum-free defined conditions. PLoS One. 5(11):e14099.

2009

  • Oki T, Eto K, Izawa K, Yamanishi Y, Inagaki N, Frampton J, Kitamura T, Kitaura J. Evidence that integrin aIIbβ3-dependent interaction of mast cells with fibrinogen exacerbates chronic inflammation. J Biol Chem 284, 31463-72.
  • Okabe M, Otsu M, Ahn DH, Kobayashi T, Wakiyama Y, Morita Y, Onodera M, Eto K, Ema H, Nakauchi H. Definitive proof for direct reprogramming of hematopoietic cells to pluripotency. Blood 114, 1764-7.
  • Ogaeri T, Eto K, Otsu M, Ema H, Nakauchi H. The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells. Stem Cells 27, 1120-9.
  • Yamazaki S, Iwama A, Takayanagi S, Eto K, Ema H, Nakauchi H. TGF-β induces hibernation of hematopoietic stem cells in the bone marrow niche. Blood 113, 1250-6.

2008

  • Nishikii H, Eto K, Tamura N, Hattori K, Heissig B, Kanaji T, Sawaguchi A, Goto S, Ware J, Nakauchi H. Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells. J Exp Med 205, 1917-27.
  • Takayama N, Nishikii H, Usui J, Tsukui H, Sawaguchi A, Hiroyama T, Eto K, Nakauchi H. Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors. Blood 111, 5298-5306.

2007

  • Eto K, Nishikii H, Ogaeri T, Suetsugu S, Kamiya A, Kobayashi T, Yamazaki D, Oda A, Takenawa T, Nakauchi H. The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery. Blood 110, 3637-3647.

2006

  • Yamazaki S, Iwama A, Takayanagi SI, Morita Y, Eto K, Ema H, Nakauchi H. Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells. EMBO J 25, 3515-3523.

2005

  • Matsubara A, Iwama A, Yamazaki S, Furuta C, Hirasawa R, Morita Y, Osawa M, Motohashi T, Eto K, Ema H, Kitamura T, Vestwever D, Nakauchi H. Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development. J Exp Med 202, 1483-1492.